The mitochondrial GSH-Px1 converts H 2 O 2 to H 2 O via oxidation of GSH to oxidized glutathione (GSSG) [101]
Semaglutide (Ozempic, Wegovy, Rybelsus) is the most prescribed
As expected by the increased striatal DA, pathways signifying activation of signalling by G-protein-coupled receptors, transmission across chemical synapses and calcium signalling were all positively enriched at 3 months in iSPN + mut (Supplementary Table 1a), whereas genes associated with metabolic pathways such as oxidative phosphorylation (OxPhos) and respiratory electron transport ATP synthesis were significantly downregulated in iSPN + mut compared to iSPN+wt at 3 months (Fig
Notartomaso S, Mascio G, Bernabucci M, Zappulla C, Scarselli P, Cannella M, et al
Thats why I believe companies like HIMS and HERS (in the US), Numan (UK) and others may be in a good position to capitalize on this and any other opportunity that emerges (think: peptides, testosterone replacement therapy and more), although regulation remains a massive risk for the time being
AbbVie spends 1315% on R&D (15.1% in 2024, plus 10% on acquired R&D)