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Researchers first found it in human plasma, where its concentration falls with age

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Ding S, Jiang J, Wang Z, Zhang G, Yin J, Wang X, et al

The available data remain largely preclinical or based on limited observations, and its non-selectivity is also its main limitation: by affecting multiple receptors, it is associated with varied effects reported in the literature

Pharmacology of GLP-1 RAs Endogenous GLP-1 is secreted from intestinal L-cells following oral nutrient intake