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Oxidative/nitrosative stress and mitochondrial dysfunction Oxidative/nitrosative stress is caused by an imbalance between the generation of reactive oxygen/nitrogen species (ROS/RNS) and antioxidant defenses, which leads to cellular and tissue damage
At less than normal therapeutic doses (e.g
Journal of Investigative Dermatology, 113(3), 364-368
van Toorn R, Solomons RS, Seddon JA, Schoeman JF
These findings underscore the capacity of strategic nutraceutical pairings to optimize pharmacological outcomes
In other words, oral isotretinoin may promote collagen production, resulting in firmer and more elastic skin
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