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Why HbA1c May Be Unreliable in B12 Deficiency B12 deficiency alters red cell turnover and erythropoiesis, making HbA1c potentially unreliable in either direction the distortion is variable and cannot be predicted
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Unknown long-term effects : Because human studies are extremely limited, we simply do not know whether prolonged use carries risks
Glucagon activation increases thermogenesis (heat production), enhances fat oxidation, and elevates metabolic rate
Resultantly, bacteriostatic water will not remain homogeneous, as an uneven concentration of bacteriostatic preservative will be present throughout the vial
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