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Where semaglutide activates only the GLP-1 receptor, tirzepatide adds GIP receptor agonism, which appears to potentiate the GLP-1 effects in ways that produce superior weight loss and metabolic outcomes compared to GLP-1 agonism alone
Serious but rare adverse effects associated with injectable GLP-1 receptor agonists include acute pancreatitis, gallbladder disease (cholecystitis and cholelithiasis), and potential thyroid effects
Nonetheless, this study demonstrated that liraglutide did not significantly change PASI and DLQI in these patients when compared with placebo
DAddario, C
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