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3407-A DIFFERENT ROLE OF GLUTAMINOLYSIS IN LUNG AND LIVER FIBROSIS Ayse Okesli Armlovich, Olga Gulyaeva, Saritha Kusam, Yeonju Lee, Wallace Liu, Wesley Minto, Kelly Staiger, Devan Naduthambi, Tina Mistry, Minji Seung, Kelli Boyd, Bhanu Singh, Bruno Marchand, Lauri Diehl, Grant Budas, Anna Zagorska and Jamie Bates, Gilead Sciences, Inc

While formulas like SZRD and KXS offer the theoretical advantage of multi-target synergy, it is challenging to identify the exact active constituents responsible for the observed anti-ferroptotic effects, to standardize their preparation, and to attribute outcomes specifically to ferroptosis modulation amidst their broad pharmacological profiles

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Results: Riboflavin supplementationparticularly in high doseshas demonstrated substantial efficacy in conditions such as riboflavin transporter deficiency (RTD), multiple acyl-CoA dehydrogenase deficiency (MADD), and migraine

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revealed that succinylation of SUCLG2 at K93 can inhibit TRIM21-mediated ubiquitination, thereby enhancing the stability of SUCLG2