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249 Nuclear STAT3-Y705 activates glycolysis and fatty acid oxidation (FAO) genes, while mitochondrial STAT3-S727 and acetylated STAT3-K685 impair oxidative phosphorylation by destabilizing electron transport chain (ETC) complexes, supporting leukemia stem cell dormancy and persistence
Buchanan ME, Davis RL
Gim mn vim, mn trng c Mn hnh thnh do l chn lng b tc, vi khun, b nhn d tha v t bo da cht
Phase II detoxification enzymes and antioxidant proteins show enhanced expression[8]
Probably, the low binding affinity is an artifact of the receptor isolation, as the physiologically relevant affinity of thiamine to the receptor may require proteinprotein interaction within the native structure of the synapses
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