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What we know about tirzepatide Tirzepatide has been studied extensively in large clinical trials
The biological reality is that most people will regain significant weight after discontinuing treatment, not because of personal failure but because of powerful biological mechanisms defending against sustained weight loss
Jamil Alkhaddo, M.D., an endocrinologist based in California
A 2024 study found that people who exercised while using weight loss drugs kept off more weight after stopping than those who didnt work out
Our guide to weaning off tirzepatide covers the tapering process, and our guide to maintaining weight loss after tirzepatide addresses the long-term picture that most people overlook during active treatment
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