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Clinical Points GLP-1 receptor agonists (GLP-1 RAs), such as exenatide, demonstrated efficacy in reducing heavy drinking days and total alcohol intake in individuals with obesity-related alcohol use disorders, suggesting a potential role for GLP-1 RAs in targeted treatments for alcohol dependency, particularly in patients with specific metabolic profiles
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
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Data available so far suggest that HFDs are associated with a reduction in intestinal bacterial diversity, changes in membrane integrity and the immune system, and low-intensity systemic inflammation
GLP-1 activation in white fat tissue may also help prevent the weight-loss-associated decrease in leptin and thus, facilitate weight loss that is sustainable over the long term [14]
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