While rodent studies prompted FDA Boxed Warnings for thyroid C-cell tumors, large-scale clinical trials in humans have not demonstrated increased overall cancer incidence with these medications
To this end, SNAP/FLAG-hGLP-1R WT or V229A-expressing adenoviruses were transduced into islets extracted from mice lacking endogenous GLP-1R expression (GLP-1R KO, generated in house )
Gastroenterology 163 , 649658.e2 (2022)
Antagonizing IAPs by SMAC Mimetic TL32711 Induces Apoptosis in AML Cells Including AML Stem/Progenitor Cells Alone and in Combination with Chemotherapy
If you were looking at trying GLP-1 medications for weight loss or blood sugar improvements, Wegovy would likely be the better choice
Theyve spent all this money on treatment, and suddenly the weight has come back on. Lastly, some patients have mentioned an impact on impulsive behaviours when the dopamine regulation effects of GLP-1 agonists appear to wear off