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Retatrutide covers all three receptors, making it the most comprehensive option for multi-pathway research

The medication enhances insulin secretion and inhibits glucagon release, which helps in maintaining stable blood glucose levels

Moreover, when GLP-1based medications are administered, they also stimulate peripheral GLP-1 receptors on vagal nerve fibers that carry sensory information from the stomach and intestines to the brainstem

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BMC Gastroenterology , 17(1), 96.