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Retatrutide is an investigational once-weekly injectable triple agonist that simultaneously activates GLP-1, GIP, and glucagon receptors to reduce appetite, increase energy expenditure, and improve metabolic control
Depending on the response, the dose may be increased to 12.5mg for weeks 17 to 20, and then to 15mg starting from week 21
These treatments are not appropriate for all patients and may be contraindicated in individuals with certain medical conditions including hormone-sensitive cancers, blood clotting disorders, severe liver disease, or cardiovascular conditions
They remain relevant as inexpensive oral alternatives for patients refusing injection or with incretin contraindications
Note down your energy levels, your bowel habits, your sleep quality, and any "mystery symptoms" like brain fog or hair thinning
Changes to the physical condition of the pen, vial, or device such as a damaged seal, cracked cartridge, leaking device, or damaged packaging should also prompt immediate discontinuation of use
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