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Summary Summary In summary, a triathlete or endurance athlete on a GLP-1 agonist must be very intentional about their nutrition, hydration, and training

Why Hormone Therapy Changes the Body Differently Hormone optimization typically works through different mechanisms

One area that has attracted academic discussion, press coverage, and significant biotechnology/pharma R&D investment is concern about undesirable, collateral skeletal muscle mass (SMM) loss, and presumably by extension, loss of strength and function in people taking GLP-1 medications

Body composition shifts are real but modest, typically a few pounds of visceral fat reduction and improved muscle definition over months, not the dramatic scale changes seen with semaglutide or tirzepatide