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Combining these advancements with other treatment modalities may further optimize their potential, creating a more comprehensive framework for managing T2DM and related metabolic disorders
For many readers, it represents the possibility that treatment may keep moving forward, with options that better match how complex metabolism really is
This increases lipophilicity, allowing ALCAR to cross the blood-brain barrier more readily than plain L-carnitine via OCTN2 transporter and passive diffusion
Limited data mostly from case-control studies are available to assess whether citicoline (CDP-choline) might improve cognitive performance in subjects with AD or PD, and studies to date have generally been labeled as poor in quality (84)
Rather than stopping abruptly, some prescribers recommend gradually extending the interval between doses
In perspective, the repositioning of this class of treatment for chemo-adjuvant protocols is of particular interest, since all these medicaments are well-characterized from a pharmacological and toxicological point of view as well as adjustment strategies in case of comorbidities, ultimately reducing failure risk and costs
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