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Selenocysteine tRNA is needed to insert selenocysteine into GPX4 13

High -tocopherol intakes, e.g., most vitamin E supplements, lead to increases in plasma -tocopherol, decreases in plasma -tocopherol (17), and increases in excretion of both -CEHC and -CEHC

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380 However, NAD + depletion exacerbates oxidative damage via reducing the antioxidant defense capacity, resulting in impaired cell proliferation and increased cell death

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