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BMJ 352 , i581 (2016)

Research using MT-1 in cell systems expressing MC1R variants associated with red hair and fair skin has characterised reduced cAMP signalling responses, impaired MITF activation, and decreased melanogenesis , documenting the functional consequences of loss-of-function MC1R polymorphisms at the receptor signalling level and establishing the molecular basis for the reduced photoprotective melanogenesis capacity associated with these variants

The material must be clearly labeled as not for human consumption and accompanied by documentation establishing its research-use intent

(2018) 362:k2932