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Micro-needling with copper peptides is still considered a topical rather than an injection-based treatment

Additional information Edited by G Melino Supplemental Information accompanies the paper on the Cell Death Discovery website ( Supplementary information Rights and permissions This work is licensed under a Creative Commons Attribution 4.0 International License

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Ibrahim IA, Shalaby AA, Abd Elaziz RT, Bahr HI

This degradation liberates iron back into the LIP, enhancing the availability of ferrous iron that can initiate the production of harmful lipid peroxides, thereby triggering the pathway of ferroptosis (50,51)