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Intramuscular injections deliver a concentrated dose directly into the blood flow and provide the highest bioavailability of active ingredients and an immediate start of action

The same applies if constipation keeps returning after every dose increase, requires frequent laxatives, or comes with new weight-loss medication side effects you cannot explain

Formulation vehicle influences absorption substantially

Tirzepatide went further, with up to 20.9% weight reduction in the SURMOUNT-1 trial (Jastreboff et al., N Engl J Med, 2022)

Canonico, M., Oger, E., Plu-Bureau, G., Conard, J., Meyer, G., Lvesque, H., Trillot, N., Barrellier, M

For more detailed information, refer to the official announcements from BCBSM and BCN (Link).