In a randomized controlled trial, tirzepatide at doses of 10 mg and 15 mg resulted in an average weight reduction of 20% and 21%, respectively, while the 5 mg dose led to a 15% weight loss, compared to 3% with placebo
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If symptoms persist beyond 812 weeks despite dietary modifications, consult your healthcare provider for evaluation and potential management adjustments
The study suggested a modest increase in the risk of NAION among individuals with type 2 diabetes who used semaglutide
Understanding these trials, what they measure, and what the results mean, is essential for anyone tracking this compound
For tirzepatide versus semaglutide, contrary to the primary endpoint in the head-to-head comparison, there was some supporting evidence for tirzepatide to have a modest benefit, although the 95% CI overlapped the null (HR 0.91, 95% CI 0.81 to 1.01) (Fig