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Note that vitamin B12 is water soluble

"If they actually are biologically active, what harm could they be doing to the body?" Caufield said

Sometimes people think they are just taking a plain B 12 or B complex and there are other things in there, like probiotics or prebiotics and other herbs

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However, someone with a more severe, long-standing deficiency might need to wait a little longer, possibly requiring multiple injections over several weeks or months to fully replenish their B12 stores and reverse symptoms

Commonly used protocols include 250 mcg twice daily or 500 mcg once daily, taken on an empty stomach 20 to 30 minutes before food