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[4] [5] The standard of care remains disease-modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs like methotrexate as first-line therapy, with escalation to biological DMARDs or targeted synthetic DMARDs if disease activity remains inadequately controlled, following a treat-to-target approach
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The STEP (Semaglutide Treatment Effect in People with obesity) trials, which evaluated semaglutide for weight management, documented gallbladder disorders in approximately 2.6% of participants receiving the medication versus 1.2% in the placebo group
Lipoylated protein aggregation is associated with the destruction of iron-sulfur cluster proteins, commonly initiated by ROS [54]
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The theoretical benefits of low-dose GLP-1 therapy for inflammation include the potential for anti-inflammatory effects with a reduced side effect burden compared to standard doses
