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Interestingly, oral administration of proniosomes loaded with amitriptyline and liraglutide showed synergistic benefits for controlling blood glucose levels, alleviated pain, reduced oxidative stress and inflammation, and improved sciatic nerve histology in diabetic rats [85]

LR3 enables interrogation of pathway dynamics across many hours to days

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Signalling from L-cells to sensory neurones in intact colon To examine whether L-cell-released ATP triggers afferent nerve signalling within the intact gut, we measured changes in mesenteric nerve activity from the proximal colon following AngII mediated L-cell activation

Second, subgroup analysis was not possible in this study

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