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The average weight loss of 2-3 kg over 12 weeks, while statistically significant, is substantially less than results achieved with appetite-suppressing medications or intensive dietary interventions

GLP-1 and GIP receptor agonists have a low intrinsic risk of causing hypoglycaemia when used alone, because their insulin-stimulating effects are glucose-dependent

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NNMT inhibition can produce anti-inflammatory effects by reducing the production of pro-inflammatory molecules

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These findings are preclinical