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Patients who remained on treatment throughout the study achieved even greater average weight loss, demonstrating the importance of adherence and gradual dose escalation

Ours is the largest trial undertaken so far and supports the use of these agents not merely to enable patients to lose weight, but also to benefit underlying diseases such as cardiovascular disease, Deanfield said, adding that hes like to see more research on the mechanisms by which GLP-1 RAs achieve weight loss, benefit multiple diseases, and result in behavioral changes that can maintain their health benefit. Yael L

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