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In the SURPASS trial data, acute pancreatitis occurred at approximately 0.23 events per 100 person-years with tirzepatide versus 0.11 with comparators roughly double the comparator rate in the controlled T2D trials, but small in absolute terms for most people

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Whilst exact mechanisms remain unclear, a combination of risk factor reduction in improved HbA1c, weight, metabolic profile, as well as direct effects of GLP-1 agonism on coronary endothelial function and improved microvascular perfusion is likely at play

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The timeline for starting a GLP-1 after weaning depends on a few factors, including how recently you delivered, how your recovery is going, whether your postpartum hormones have stabilized, and whether you meet the clinical criteria for a GLP-1 prescription