Wegovy has been approved for weight management since June 2021
Side effects are usually mild and can be managed at home by eating small, plain meals, staying hydrated, and taking over-the-counter painkillers if needed
However, this reduced side effect profile reflects reduced efficacy, not superior safety or outcomes
In practice, it seems better to tailor the choice to different patients, depending on the preference of the route of administration (oral vs injectable), the presence of intolerance or side-effects, and contraindications
Orforglipron is currently available for weight loss as brand-name Foundayo on Ro and LillyDirect, the manufacturers direct-to-patient program
Overall, these results demonstrate that GLP-1 RAs may exert their therapeutic effects through multiple mechanisms in MASH treatment