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BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids, with the primary sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Derived from a highly stable, naturally occurring protein fragment isolated from gastric juice, this peptide is engineered via solid-phase synthesis for structural stability in laboratory environments
For example, exosomal circUSP7 from NSCLC cells inhibits miR-934 in CD8 T cells, upregulates SHP2, suppresses effector cytokine secretion (e.g., TNF-, IFN-), and induces T-cell exhaustion, thereby impairing anti-PD-1 efficacy
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