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BPC-157 work centres on local angiogenic signalling, with Hsieh and colleagues (J Mol Med, 2017) reporting VEGFR2 upregulation and internalisation in human endothelial cells, and Chang and colleagues (J Appl Physiol, 2011) reporting increased focal adhesion kinase and paxillin phosphorylation in cultured rat tendon fibroblasts

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(8) As both TB-500 and BPC-157 peptides appear to exhibit similar pharmacological potential, when blended together, the potential action of both may be maximized what would otherwise occur with one peptide, might occur at a better, faster rate when combined

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We also considered potential biological mechanisms underlying these effects, integrating insights from molecular and physiological studies

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