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In the future, the specific mechanism of action of trimetazidine in myocardial energy metabolism can be investigated by optimizing the dosage and regimen, further research, and exploring its interaction with other metabolic pathways

Regular follow-up during dose titration enables timely intervention when problems arise

Last reviewed: May 12, 2026 Last updated: May 12, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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These medicationsincluding semaglutide (injectable Ozempic, oral Rybelsus, injectable Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)mimic the action of endogenous GLP-1 while resisting degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)

This led the authors to speculate that Fusobacteria increased as a protection mechanism against ammonia toxicity in the intestine, although the mechanism remains unclear