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Upregulated: collagen synthesis genes (COL1A1, COL3A1), antioxidant genes (SOD1, SOD3), DNA repair genes (GADD45A) Downregulated: inflammatory cytokines (IL-6, TNF-), metalloproteinases (MMP-2, MMP-9), pro-fibrotic mediators Net effect: shift from tissue destruction and inflammation toward repair and remodeling This breadth of gene modulation is unusual for a single tripeptide and has generated significant research interest in fields ranging from dermatology to neuroscience
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The compound has accumulated over 130 published research papers spanning three decades, with studies demonstrating consistent healing effects across tendons, ligaments, muscles, the gastrointestinal tract, and even nerve tissue
Multiple mechanisms of action The peptides under investigation for psoriasis do not all work the same way
Once reconstituted for laboratory use, solutions should be kept at 4C and used within 48 to 72 hours
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