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Based on this comprehensive assessment, they will develop a treatment plan using GLP-1 medications

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More Complex Mechanism = More Complex Risks Activating two pathways may have unforeseen interactions GIPs role in gastrointestinal function not fully understood Potential for different or additional side effects beyond GLP-1 alone 3

SGLT2 inhibitors inhibit glucose and sodium reabsorption in the proximal renal tubule, promoting glucosuria and macula densa activation, resulting in a reduction in glomerular pressure and glomerular hyperfiltration [46, 47]

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Stress increases aldosterone, producing water retention and high blood pressure