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25,26 Effects on Epicardial Adipose Tissue GLP1-RAs decrease the volume of epicardial adipose tissue, which is often elevated in HFpEF and is a source of proinflammatory cytokines and adipokines

Retatrutide, as a triple agonist, adds glucagon receptor activation, further controlling appetite and enhancing energy expenditure

However, they found other, not-so-commonly reported side effects still showing up as significant

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