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Growth hormone exerts an anti-catabolic effect during energy restriction, helping preserve lean mass. Jrgensen, J.O.L., Growth Hormone & IGF Research 3
Accumulation of these compounds can result in oxidative stress, which occurs when the generation of free radicals in the body exceeds the bodys ability to neutralize and eliminate them
But a 2015 randomized control trial with 218 healthy adults found no direct links between calorie restriction and serum IGF-1 levels
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