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A second well-documented line of work concerns growth factor receptor expression

The International Peptide Society notes that epitalon administered intranasally would require two to three times the injectable dosage to achieve comparable effects

This prevents learning individual response at lower amounts and wastes product if lower doses would suffice

However, not all peptides are created equal

Its working mechanism is allosteric facilitation of HGF/c-Met signaling: Dihexa binds HGF with high affinity (reported K d ~65 pM in the original work) and is proposed to potentiate HGF dimerization and c-Met phosphorylation at subthreshold endogenous HGF concentrations