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10.1016/j.cmet.2012.12.011

A drug might have a compound patent expiring in Year 10, an NCE exclusivity running to Year 5, formulation patents running to Year 14, and pediatric exclusivity adding six months to everything producing an effective exclusivity window that extends to Year 14.5, despite a nominal compound patent expiry in Year 10

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Subsequently, patients are advised to escalate their intake by increasing the dosage to a daily measurement of 7 mg3