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The FDA-approved versions of semaglutide are based on: Tons of clinical studies and research on real people Obtaining consistent results with each dose Stringent quality control measures that the manufacturer must comply with Clear instructions for usage Compounded versions of semaglutide: Are not FDA-approved Have a difference in quality between different pharmacies May not have the same mix of ingredients each time Do not have proof that they actually work (no validated efficacy data) Is compounded semaglutide safe
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J Clin Neurosci 63:168175
The CREDENCE trial (Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation) also evaluated the cardiovascular risk reduction of canagliflozin, but in patients with type 2 diabetes and established chronic kidney disease
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