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Neurotrophins such as BDNF and NGF play central roles in synaptic plasticity, neuronal survival, and network organization, and their dysregulation may represent a more proximal mechanism underlying behavioral impairments
Tsai et al., 1998) mainly in the PFC, but not in other cortical or brain regions such as the cingulate cortex, hippocampus or cerebellar vermis (Freund and Anderson, 2008)
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