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While the impact of each of these beneficial effects is individually important, many of these obesity-related complications act synergistically to increase the risk of cardiovascular disease
have provided evidence that tofacitinib directly modulates mitochondrial function, such as regulating key mitochondrial genes, increasing oxidative phosphorylation, enhancing ATP production while diminishing glycolytic flow and key glycolytic genes (162)
It is also more costly and may not be necessary for everyone
Presented for research literature review only Chi H et al
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