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Aladdin, China) was administered to mice by adding to drinking water for 16 weeks, and was changed to fresh twice a week

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Antonoff MB , Simon GR, Gold KA, Patel S, Gomez D, Ferrarotto R, Allen J, Stevens R, Suarez Saiz FJ, Berger M, Walsh G, Mynhier M, High R, Futreal A, Hahn S, Swisher S, Heymach J, Chin L

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Adverse reaction 1) If overdose, the following adverse reactions may occur: Headache, asthenia, fatigue, muscle pain, Loss of appetite, weight loss, growth disorder, nausea, vomiting, constipation, diarrhea, polydipsia, polyuria, dehydration, high blood pressure, calcium oxalate stones, tissue calcification, kidney disease, vascular disease, and kidney failure