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In non-diabetic individuals using semaglutide for weight loss, A1C may decrease modestly from baseline, especially if it was borderline elevated before treatment
(November 14, 2025)
These medications work through entirely different mechanisms in the body and do not interfere with each other's pharmacological pathways
however, a dedicated kidney outcome trial with semaglutide was recently stopped early for efficacy and data are awaited in 2024 [8]
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