Nausea was reported in 42.4% of patients on the 12 mg dose, with diarrhoea and constipation affecting 32% and 26.1% respectively
It also reduces the risk of cardiovascular adverse events like stroke, heart attack, and hypertension
Thus, novel therapeutic approaches that exert renoprotective effects independently of these factors have been awaited
This progress was also supported by the histological findings
Key domains requiring structured oversight include: Pancreatitis and gallbladder disease Progression of diabetic retinopathy Severe gastrointestinal intolerance Visual loss and rare opticnerve complications Nutritional/metabolic issues with rapid weight reduction In India, where continuity of care is variable and prescribing often occurs outside endocrinology, these risks can be underrecognised or misattributed
SNAC enhances absorption by neutralizing the pH in the stomach, protecting the drug from degradation by gastric enzymes and increasing membrane permeability