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146 Sapidolide A, extracted from a folk medicine used in China to treat inflammatory diseases, inhibits expression and activation of the NLRP3 inflammasome when used as a pretreatment in a mouse model of APAP-induced liver injury
At 8 weeks of age, mice were intraperitoneally administered STZ (50 mg/kg/day) for 5 consecutive days
This phase coincides with early weight loss, which can increase bile cholesterol concentration and promote gallstone formation
The absorbed drug may undergo first pass metabolism in the intestinal wall/liver or be excreted in bile
While the Phase 2 trial did not specifically stratify outcomes by baseline eGFR, GLP-1 receptor agonists as a class have demonstrated renoprotective effects in at-risk populations
In summary, Arakawa M, et al
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