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Because appetite and thirst signals may both decrease, many users unintentionally fall behind on fluid intake throughout the day without noticing immediately, which can lead to dehydration on GLP-1 medications if left unaddressed

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Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications