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Many human RCTs included in this review (e.g., Kadouh et al., 2020
Moreover IR in PCOS was shown to destroy the effect of gonadotropins, enhance the sensitivity of follicular membrane cells to the luteinizing hormone, and increase the expression of P450c17 and 3-hydroxysteroid dehydrogenase type 2, leading to increased production of androgen (152)
The medication continues working to maintain that new set point, which is why discontinuation often leads to weight regain
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Diarrhoea, vomiting, constipation, and abdominal pain were also amongst the most frequently observed side effects
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