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On the other hand, Kupffer cell-derived IL-10 can restrict the injury by limiting iNOS induction [100, 101] and at later time points by promoting pro-regenerative gene expression in hepatocytes surrounding the area of necrosis [102]

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Indirect stimulation has also been demonstrated by bradykinin (366), NGF (366), PGE2 (369), PGI2 (369) and agonists of Protease-activated Receptors (PARs) (370)