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In turn, macrophage-derived IL-6 activates STAT3 signaling in CRC cells, facilitating c-Myc transcription and transforming macrophages into a pro-tumor M2-like phenotype, which promotes tumorigenesis

Brand-name medications such as Ozempic and Wegovy may be prescribed when clinically appropriate and are FDA-approved for specific indications

Its altered IGFBP binding profile makes it a useful tool for studying IGF-1 receptor activation independent of binding-protein dynamics