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In Phase 2 obesity trials, retatrutide produced approximately 24% mean body-weight reduction at 48 weeks at the 12 mg dose the largest weight-loss effect reported for any GLP-1-class compound to date

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In the sagittal view, ROIs were placed for the spleen (5 cm 3 ), liver (50 cm 3 ), 2 kidneys (1 cm 3 ), 2 biceps (15 cm 3 ), 2 thighs (15 cm 3 )