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We begin by delineating intrinsic and acquired resistance pathways, including alterations in drug transport and metabolism, signaling rewiring, epigenetic remodeling, the DNA damage response, and tumor microenvironmental adaptation
The transition from the second molten-globule state to a near native conformer was required to cross a higher energy barrier during BE-META (88)
10.1677/joe.1.06159 J
Supports the bodys natural detoxification and immune function
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