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Week 1: Early Pharmacodynamic Changes What the trials documented: The Phase 1b combination study measured reduced food intake and slowed gastric emptying among the earliest pharmacodynamic signals after dosing began, while the dose was still at the lowest titration step (Enebo et al., 2021)

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This dose was chosen based on a previous dose-escalation study and subsequent work demonstrating its efficacy to drive weight loss in a short period of time 8

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Sehgal P, Gupta R, Choudhary K, Singh R BPC 157: A Promising Candidate for Cytoprotection and Tissue Repair

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