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For semaglutide, there are several key contraindications: Personal or Family History of Medullary Thyroid Carcinoma (MTC): Semaglutide is not recommended for people who have or have had MTC or if their family has a history of this type of thyroid cancer
"In 9 hours, 134 nanomoles of peptide and 705 nanomoles of copper permeated through microneedle-treated human skin, while almost no peptide or copper permeated through intact skin." That is the Li et al
GLP-1s are generally safe, but some drugs have been withdrawn from the market due to long-term risks
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